368007 6-Aminocaproic acid - AK Scientific
 
 
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  Catalog ID # 368007
6-Aminocaproic acid
, 99%
 
Aminocaproic acid
Amicar
6-aminohexanoic acid
EACA




IDENTITY
CAS Registry #:[60-32-2]
MDL Number:MFCD00008238
MF:C6H13NO2
MW:131.17
EINECS:200-469-3
BRN:906872
SPECIFICATIONS & PROPERTIES
Purity:99%
Physical Form:White crystalline powder
Melting Point:204-212°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: 6mg/mL; H2O: 26mg/mL; EtOH: 1mg/mL
Application(s):Antifibrinolytic Agent; Proteolytic Enzyme Inhibitor
Form:Free Base

REVIEW

 Aminocaproic acid is used to treat excessive postoperative bleeding. It is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis.

REFERENCES
[1]Thondorf I, Voigt V, Sch?fer S, Gebauer S, Zebisch K, Laug L, Brandsch M (2011). Three-dimensional quantitative structure-activity relationship analyses of substrates of the human proton-coupled amino acid transporter 1 (hPAT1). Bioorg Med Chem. 19(21):6409-18. PMID 21955456.
[2] Banerjee A, Stoica C, Walia A (2011). Acute hyperkalemia as a complication of intravenous therapy with epsilon-aminocaproic acid. J Clin Anesth. 23(7):565-8. PMID 22050802.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.



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CATEGORIES

 APIs and Bioactives > Antihemorrhagics
 Amino Acids > Unnatural Amino Acids

USEFUL LINKS

  PubChem