66678 Tamibarotene - AK Scientific
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  Catalog ID # 66678
, 98% (HPLC)
AM 80

CAS Registry #:[94497-51-5]
MDL Number:MFCD00866188
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:190-195°C
Shipping:Normal Temperature

Solubility:DMSO: >=10 mg/mL
Application(s):Agonist for retinoic acid receptor alpha/beta


 Tamibarotene is an orally-active, synthetic retinoid, developed to overcome all-trans retinoic acid resistance, with potential antineoplastic activity. It is a retinoic acid receptor (RAR) agonist with high specificity for RARalpha and RARbeta over RARgamma that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. It is considered to be a promising candidate drug for treatment of Alzheimer's disease because of its transcriptional controls of multiple target genes involved in etiology and pathology of Alzheimer's disease.

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[2] Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi; Himi, Toshiyuki Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity Journal of Medicinal Chemistry (1988), 31(11), 2182-92.
[3] Hamada, Yoshinori; Yamada, Isamu; Uenaka, Masaaki; Sakata, Teruo Preparation of 4-[(5,6,7,8-tetrahydro-5,6,8,8-terramethyl-2-naphthalenyl)carbamoyl]benzoic acid derivatives PCT Int. Appl. (1991), WO 9114673 A1 19911003.
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[5] Nagai H; Matsuura S; Bouda K; Takaoka Y; Wang T; Niwa S; Shudo K Effect of Am-80, a synthetic derivative of retinoid, on experimental arthritis in mice Pharmacology (1999), 58(2), 101-12.
[6] Takeuchi M, Yano T, Omoto E, Takahashi K, Kibata M, Shudo K, Harada M, Ueda R, Ohno R Relapsed acute promyelocytic leukemia previously treated with all-trans retinoic acid: clinical experience with a new synthetic retinoid, Am-80.Leuk Lymphoma. 1998 Nov;31(5-6):441-51.
[7] Tamibarotene: AM 80, retinobenzoic acid, Tamibaro. Drugs R D. 2004;5(6):359-62.

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