66678 Tamibarotene - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # 66678
Tamibarotene
, 98% (HPLC)
 
AM 80
Amibaro
Amnolake
Amnoleuk




IDENTITY
CAS Registry #:[94497-51-5]
MDL Number:MFCD00866188
MF:C22H25NO3
MW:351.444
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:190-195°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: >=10 mg/mL
Application(s):Agonist for retinoic acid receptor alpha/beta

REVIEW

 Tamibarotene is an orally-active, synthetic retinoid, developed to overcome all-trans retinoic acid resistance, with potential antineoplastic activity. It is a retinoic acid receptor (RAR) agonist with high specificity for RARalpha and RARbeta over RARgamma that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. It is considered to be a promising candidate drug for treatment of Alzheimer's disease because of its transcriptional controls of multiple target genes involved in etiology and pathology of Alzheimer's disease.

REFERENCES
[1]Shudo, Koichi Benzoic acid derivatives Eur. Pat. Appl. (1986), EP 170105 A2 19860205.
[2] Kagechika, Hiroyuki; Kawachi, Emiko; Hashimoto, Yuichi; Shudo, Koichi; Himi, Toshiyuki Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity Journal of Medicinal Chemistry (1988), 31(11), 2182-92.
[3] Hamada, Yoshinori; Yamada, Isamu; Uenaka, Masaaki; Sakata, Teruo Preparation of 4-[(5,6,7,8-tetrahydro-5,6,8,8-terramethyl-2-naphthalenyl)carbamoyl]benzoic acid derivatives PCT Int. Appl. (1991), WO 9114673 A1 19911003.
[4] Eyrolles L; Kagechika H; Kawachi E; Fukasawa H; Iijima T; Matsushima Y; Hashimoto Y; Shudo K Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring Journal of medicinal chemistry (1994), 37(10), 1508-17.
[5] Nagai H; Matsuura S; Bouda K; Takaoka Y; Wang T; Niwa S; Shudo K Effect of Am-80, a synthetic derivative of retinoid, on experimental arthritis in mice Pharmacology (1999), 58(2), 101-12.
[6] Takeuchi M, Yano T, Omoto E, Takahashi K, Kibata M, Shudo K, Harada M, Ueda R, Ohno R Relapsed acute promyelocytic leukemia previously treated with all-trans retinoic acid: clinical experience with a new synthetic retinoid, Am-80.Leuk Lymphoma. 1998 Nov;31(5-6):441-51.
[7] Tamibarotene: AM 80, retinobenzoic acid, Tamibaro. Drugs R D. 2004;5(6):359-62.




Pricing (not showing? please refresh your web browser)

CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem  @PubMed