67526 5-Fluorouracil - AK Scientific
 
 
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  Catalog ID # 67526
5-Fluorouracil
, 98% (HPLC)
 
2,4-Dihydroxy-5-fluoropyrimidine
5-FU
5-Fluoro-2,4(1H,3H)-pyrimidinedione




IDENTITY
CAS Registry #:[51-21-8]
MDL Number:MFCD00006018
MF:C4H3FN2O2
MW:130.0772
EINECS:200-085-6
BRN:127172
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:HPLC
Physical Form:White to off-white crystalline powder
Melting Point:278-291°C
Boiling Point:190-200°C (0.1mmHg)
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: 26mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL; MeOH; 1M NH4OH
Application(s):Thymidylate synthase inhibitor; DNA Synthesis
Form:Free Base

REVIEW

 An antimetabolite that is used for treatment of cancer. Fluorouracil is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase.

REFERENCES
[1]Khan MA, Masood N, Husain N, Ahmad B, Aziz T, Naeem A (2012). A retrospective study of cardiotoxicities induced by 5-fluouracil (5-FU) and 5-FU based chemotherapy regimens in Pakistani adult cancer patients at Shaukat Khanum Memorial Cancer Hospital & Research Center. J Pak Med Assoc. 62(5):430-4. PMID 22755303.

Risk Description(s)
R25:Toxic if swallowed.
R52:Harmful to aquatic organisms.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CATEGORIES

 Heterocyclic Building Blocks > Pyrimidines, Ketones, Fluorine
 APIs and Bioactives > Chemotherapeutics
  Nucleobases > Pyrimidines

USEFUL LINKS

  PubChem