69105 Balsalazide disodium salt dihydrate - AK Scientific
 
 
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  Catalog ID # 69105
Balsalazide disodium salt dihydrate
, 98%
 
5-[4-(2-Carboxyethylcarbamoyl)phenylazo]salicylic acid disodium salt hydrate




IDENTITY
CAS Registry #:[150399-21-6]
MDL Number:MFCD01631117
MF:C17H13N3O6.2Na.2H2O
MW:437.3117
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:Yellow to brown-yellow crystalline powder
Melting Point:350 °C
Long-Term Storage:Store at 2-8°C
Shipping:Normal Temperature

REVIEW

 The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid), and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites), is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase.

REFERENCES
[1]Wiggins JB, Rajapakse R: Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1279-84.
[2] Ragunath K, Williams JG: Review article: balsalazide therapy in ulcerative colitis. Aliment Pharmacol Ther. 2001 Oct;15(10):1549-54.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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RELATED PRODUCTS
M003Balsalazide disodium
69105Balsalazide disodium salt dihydrate

CATEGORIES

 APIs and Bioactives > GI Diseases

USEFUL LINKS

  PubChem