70624 Diltiazem HCl - AK Scientific
 
 
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  Catalog ID # 70624
Diltiazem HCl
, 98% (HPLC)
 
(+)-cis-Diltiazem hydrochloride
(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401




IDENTITY
CAS Registry #:[33286-22-5]
MDL Number:MFCD00069252
MF:C22H26N2O4S.HCl
MW:450.9788
EINECS:251-443-3
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, HPLC, LCMS, Polarimetry
Physical Form:White to off-white powder
Melting Point:210-216°C
Optical Rotation:+114.0° - +122.0 ° (c=1, H2O)
Long-Term Storage:keep 2-8°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Application(s):Benzothiazepine derivative
Form:HCl salt

REVIEW

 Possibly by deforming the channel, inhibiting ion-control gating mechanisms, and/or interfering with the release of calcium from the sarcoplasmic reticulum, diltiazem, like verapamil, inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The resultant inhibition of the contractile processes of the myocardial smooth muscle cells leads to dilation of the coronary and systemic arteries and improved oxygen delivery to the myocardial tissue.

Risk Description(s)
R22:Harmful if swallowed.

Safety Description(s)
S36:Wear suitable protective clothing.



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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers

USEFUL LINKS

  PubChem