70667 Betamethasone - AK Scientific
 
 
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  Catalog ID # 70667
Betamethasone
, 98%
 
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione




IDENTITY
CAS Registry #:[378-44-9]
MDL Number:MFCD00062969
MF:C22H29FO5
MW:392.46
EINECS:206-825-4
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder
Melting Point:235-246°C
Optical Rotation:+115° - +121° (c=1, Dioxane)
Shipping:Normal Temperature

REVIEW

 Betamethasone is glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. Betamethasone is a glucocorticoid receptor agonist.

REFERENCES
[1]Saraceno R, Gramiccia T, Frascione P, Chimenti S. Calcipotriene/betamethasone in the treatment of psoriasis: a review article. Expert Opin Pharmacother. (2009) Oct;10(14): 2357-65.
[2] Giardino G, Fusco A, Romano R, Gallo V, Maio F, Esposito T, Palamaro L, Parenti G, Salerno MC, Vajro P, Pignata C. Betamethasone therapy in ataxia telangiectasia: unraveling the rationale of this serendipitous observation on the basis of the pathogenesis. Eur J Neurol. (2013) May;20(5): 740-7.
[3] Basaran A, Basaran M, Sen C. Choice of glucocorticoid in HELLP syndrome - dexamethasone versus betamethasone: revisiting the dilemma. J Matern Fetal Neonatal Med. (2012) Dec;25(12): 2597-600.
[4] Taub, D.; Hoffsommer, R. D.; Slates, H. L.; Kuo, C. H.; Wendler, N. L.16beta-Methyl cortical steroids Journal of the American Chemical Society (1960), 82, 4012-26.

Risk Description(s)
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



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CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem