70667 Betamethasone - AK Scientific
 
 
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  Catalog ID # 70667
Betamethasone
, 98%
 
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione




IDENTITY
CAS Registry #:[378-44-9]
MDL Number:MFCD00062969
MF:C22H29FO5
MW:392.4611
EINECS:206-825-4
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder
Melting Point:235-246°C
Optical Rotation:+115° - +121° (c=1, Dioxane)
Shipping:Normal Temperature

REVIEW

 Betamethasone is glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. Betamethasone is a glucocorticoid receptor agonist.

REFERENCES
[1]Saraceno R, Gramiccia T, Frascione P, Chimenti S. Calcipotriene/betamethasone in the treatment of psoriasis: a review article. Expert Opin Pharmacother. (2009) Oct;10(14): 2357-65.
[2] Giardino G, Fusco A, Romano R, Gallo V, Maio F, Esposito T, Palamaro L, Parenti G, Salerno MC, Vajro P, Pignata C. Betamethasone therapy in ataxia telangiectasia: unraveling the rationale of this serendipitous observation on the basis of the pathogenesis. Eur J Neurol. (2013) May;20(5): 740-7.
[3] Basaran A, Basaran M, Sen C. Choice of glucocorticoid in HELLP syndrome - dexamethasone versus betamethasone: revisiting the dilemma. J Matern Fetal Neonatal Med. (2012) Dec;25(12): 2597-600.
[4] Taub, D.; Hoffsommer, R. D.; Slates, H. L.; Kuo, C. H.; Wendler, N. L.16beta-Methyl cortical steroids Journal of the American Chemical Society (1960), 82, 4012-26.
[5] Gerber, Herbert A.Hydrohalogenation of 9,11-epoxy steroids (1963), US 3086032 19630416.
[6] 9alpha-Halo-11beta-hydroxy steroids (1964), NL 288254 19640127.
[7] Kongkathip, Ngampong; Kongkathip, Boonsong; Noimai, Naratitt Synthesis of Betamethasone From the Waste of Thai Agave Sisalana Synthetic Communications (2006), 36(7), 865-874.
[8] Murphy, Kellie E.Betamethasone compared with dexamethasone for preterm birth: a call for trials Obstetrics & Gynecology (Hagerstown, MD, United States) (2007), 110(1), 7-9.
[9] Ruffatti A, Marson P, Svaluto-Moreolo G, Marozio L, Tibaldi M, Favaro M, Calligaro A, Grava C, Hoxha A, Pengo V, Punzi L.A combination therapy protocol of plasmapheresis, intravenous immunoglobulins andbetamethasone to treat anti-Ro/La-related congenital atrioventricular block. A case series andreview of the literature. Autoimmun Rev. 2013 May;12(7):768-73.
[10] Shepherd J, Taheri A, Feldman SR.Once-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulation. Clin Cosmet Investig Dermatol. 2013 Dec 19;7:19-22

Risk Description(s)
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



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CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem