70667 Betamethasone - AK Scientific
 
 
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  Catalog ID # 70667
Betamethasone
, 98%
 
9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione




IDENTITY
CAS Registry #:[378-44-9]
MDL Number:MFCD00062969
MF:C22H29FO5
MW:392.4611
EINECS:206-825-4
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder
Melting Point:235-246°C
Optical Rotation:+115° - +121° (c=1, Dioxane)
Shipping:Normal Temperature

REVIEW

 Betamethasone is a glucocorticoid receptor agonist. This leads to changes in genetic expression once this complex binds to the GRE. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Betamethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.

Risk Description(s)
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



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CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem