70768 Diosgenin - AK Scientific
 
 
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  Catalog ID # 70768
Diosgenin
, 98%
 
Nitogenin
3-beta-Hydroxy-5-spirostene
22alpha-Spirost-5-en-3beta-ol
(25R)-5-Spirosten-3beta-ol, 3beta-Hydroxy-5-spirostene




IDENTITY
CAS Registry #:[512-04-9]
MDL Number:MFCD00016887
MF:C27H42O3
MW:414.6206
EINECS:208-134-3
BRN:94582
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to light yellow to off-white powder
Melting Point:209-212°C
Optical Rotation:-126 ° (c=1,CHCl3)
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:CHCl3: 50mg/mL
Application(s):Steroid sapogenin
Form:Free Base

REVIEW

 Diosgenin, a steroid sapogenin, is the product of hydrolysis by acids, strong bases, or enzymes of saponins. Diosgenin is the precursor for the semisynthesis of progesterone which in turn was used in early combined oral contraceptive pills. The unmodified steroid has estrogenic activity and can reduce the level of serum cholesterol.

REFERENCES
[1]Alcantara EH, Shin MY, Sohn HY, Park YM, Kim T, Lim JH, Jeong HJ, Kwon ST, Kwun IS (2011). Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells. J Nutr Biochem. 22(11):1055-63. PMID 21292464.
[2] Xiao L, Guo D, Hu C, Shen W, Shan L, Li C, Liu X, Yang W, Zhang W, He C (2012). Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination. Glia. 60(7):1037-52. PMID 22461009.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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 APIs and Bioactives

USEFUL LINKS

  @PubChem  @Wikipedia