70768 Diosgenin - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # 70768
Diosgenin
, 98%
 
Nitogenin
3-beta-Hydroxy-5-spirostene
22alpha-Spirost-5-en-3beta-ol
(25R)-5-Spirosten-3beta-ol, 3beta-Hydroxy-5-spirostene




IDENTITY
CAS Registry #:[512-04-9]
MDL Number:MFCD00016887
MF:C27H42O3
MW:414.6206
EINECS:208-134-3
BRN:94582
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to light yellow to off-white powder
Melting Point:209-212°C
Optical Rotation:-126 ° (c=1,CHCl3)
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:CHCl3: 50mg/mL
Application(s):Steroid sapogenin
Form:Free Base

REVIEW

 Diosgenin, a steroid sapogenin triterpene, is the product of hydrolysis by acids, strong bases, or enzymes of saponins, extracted from the tubers of Dioscorea wild yam, such as the Kokoro. It has estrogenic activity and can reduce the level of serum cholesterol.

REFERENCES
[1]Mirunalini, S.; Shahira. Novel effects of diosgenin-a plant derived steroid; a review. Pharmacologyonline. (2011) (1, Newsletter): 726-736.
[2] Raju, Jayadev; Rao, Chinthalapally V. Diosgenin, a steroid saponin constituent of yams and fenugreek: emerging evidence for applications in medicine, Edited by Rasooli, Iraj. Bioactive Compounds in Phytomedicine. (2011): 125-142.
[3] Patel, Kanika; Gadewar, Manoj; Tahilyani, Vijay; Patel, Dinesh Kumar. A review on pharmacological and analytical aspects of diosgenin: a concise report. Natural Products and Bioprospecting. (2012) 2(2): 46-52.
[4] Rokem, J. S.; Tal, B.; Goldberg, I.Methods for increasing diosgenin production by Dioscorea cells in suspension cultures Journal of Natural Products (1985), 48(2), 210-22
[5] Jaggi, R. K.; Kapoor, V. K. Diosgenin - its occurrence in nature and production Indian Drugs (1992), 29(5), 191-218.
[6] Jaggi, R. K.; Kapoor, V. K.Tissue culture production of diosgenin Indian Drugs (1993), 30(8), 416-21.
[7] Pan, Helin; Chen, Chen Progress on clean and efficient utilization of yam resources Shanghai Huagong (2009), 34(6), 22-29
[8] Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin.Raju J, Mehta R. Nutr Cancer. 2009;61(1):27-35.
[9] Tong WY, Dong X.Microbial biotransformation: recent developments on steroid drugs. Recent Pat Biotechnol. 2009;3(2):141-53.
[10] Yadav VR, Prasad S, Sung B, Kannappan R, Aggarwal BB.Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.
[11] Man S, Gao W, Zhang Y, Huang L, Liu C.Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia. 2010 Oct;81(7):703-14
[12] Vasanthi HR, ShriShriMal N, Das DK.Phytochemicals from plants to combat cardiovascular disease. Curr Med Chem. 2012;19(14):2242-51

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


Pricing (not showing? please refresh your web browser)

CATEGORIES

 APIs and Bioactives

USEFUL LINKS

  PubChem