Manual review is required before order is released.
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
CHCl3: 25mg/mL
Application(s):
Estrogen Antagonist
Form:
Free Base
REVIEW Danazol is a derivative of the synthetic steroid ethisterone, a modified progestogen, also known as 17-alpha-ethinyl testosterone. Danazol inhibits ovarian steroidogenesis resulting in decreased secretion of estradiol and may increase androgens. It is also used to treat fibrocystic breast disease (in patients unresponsive to simple measures) and for the prophylactic treatment of all types of hereditary angioedema in males and females. Danazol has antigonadotropic and anti-estrogenic activities. Danazol acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. In the treatment of endometriosis, as a consequence of suppression of ovarian function, danazol causes both normal and ectopic endometrial tissues to become inactive and atrophic. This leads to anovulation and associated amenorrhea.
REFERENCES
[1]
Thomas GW, Rael LT, Bar-Or R, Mains CW, Slone DS, Boyd SR, Bar-Or D (2012). Biphasic effect of danazol on human vascular endothelial cell permeability and f-actin cytoskeleton dynamics. Biochem Biophys Res Commun. 421(4):707-12. PMID 22542943.
[2]
Uchiyama M, Jin X, Zhang Q, Hirai T, Bashuda H, Watanabe T, Amano A, Niimi M (2012). Danazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4(+) cells in mice. Transpl Int. 25(3):357-65. PMID 22239184.
All products are stocked and shipped from San Francisco Bay Area, California, USA.
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All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Danazol, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.
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