797-63-7 Levonorgestrel AKSci H088
 
 
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  H088    AKSci Reference Standard
Levonorgestrel, 98% (HPLC)
 
D-Norgestrel
Microval
Postinor
more..
IDENTITY
CAS Number:797-63-7
MDL Number:MFCD00199013
MF:C21H28O2
MW:312.45
EINECS:212-349-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:232-240°C
Optical Rotation:-31 ~ -34° (c=1, CHCl3)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 63mg/mL; H2O: <1mg/mL; EtOH: 6mg/mL
Application(s):Steroid hormone receptors
Form:Free Base

REVIEW
 Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like levonorgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

REFERENCES
[1]Kaneshiro B, Edelman A, Carlson NE, Nichols M, Jensen J (2012). Unscheduled bleeding with continuous oral contraceptive pills: a comparison of progestin dose. Contraception. 86(1):22-7. PMID 22176792.
[2] Archer DF, Stanczyk FZ, Rubin A, Foegh M (2012). Ethinyl estradiol and levonorgestrel pharmacokinetics with a low-dose transdermal contraceptive delivery system, AG200-15: a randomized controlled trial. Contraception. 85(6):595-601. PMID 22133660.
[3] Edgren RA, Stanczyk FZ: Nomenclature of the gonane progestins. Contraception. 1999 Dec;60(6):313.
[4] Sitruk-Ware R: New progestagens for contraceptive use. Hum Reprod Update. 2006 Mar-Apr;12(2):169-78. Epub 2005 Nov 16.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H312+H332; H351; H360

Precautionary Statements
P201; P202; P261; P271; P280; P302+P352; P304+P340; P308+P313; P322; P363; P405; P501

Current as of April 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Levonorgestrel, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Steroid Hormones


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