H498 (+/-)-Sulpiride - AK Scientific
 
 
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  Catalog ID # H498
(+/-)-Sulpiride
, 98% (HPLC)
 
)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
)-N-1-(Ethylpyrrolidin-2-ylmethyl)-2-methoxy-5-sulfamoylbenzamide




IDENTITY
CAS Registry #:[15676-16-1]
MDL Number:MFCD00055061
MF:C15H23N3O4S
MW:341.4258
EINECS:239-753-7
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC, Polarimetry
Physical Form:White to yellow crystalline powder
Melting Point:178-187°C
Optical Rotation:-3.0° - +3.0° (c=0.5, DMF)
Long-Term Storage:Store long-term at 2-8°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:0.1M HCl; EtOH
Application(s):A D2DR inhibitor

REVIEW

 In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors.

REFERENCES
[1]Ratomponirina C, Gobaille S, Hod? Y, Kemmel V, Maitre M (Apr 1998). "Sulpiride, but not haloperidol, up-regulates gamma-hydroxybutyrate receptors in vivo and in cultured cells". Eur J Pharmacol. 346 (2-3): 331-7. doi:10.1016/S0014-2999(98)00068-5. PMID 9652377.
[2] Maitre M, Ratomponirina C, Gobaille S, Hod? Y, Hechler V (Apr 1994). "Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics". Eur J Pharmacol. 256 (2): 211-4. doi:10.1016/0014-2999(94)90248-8. PMID 7914168.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.



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CATEGORIES

 APIs and Bioactives > Antipsychotics

USEFUL LINKS

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