H500 2-Methylnaphthoquinone - AK Scientific
 
 
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  Catalog ID # H500
2-Methylnaphthoquinone
, 97% (HPLC)
 
Menadione




IDENTITY
CAS Registry #:[58-27-5]
MDL Number:MFCD00001681
MF:C11H8O2
MW:172.18
EINECS:200-372-6
BRN:1908453
SPECIFICATIONS & PROPERTIES
Purity:97% (HPLC)
Physical Form:Yellow to yellow-green powder
Melting Point:104-108°C
Shipping:Normal Temperature

REVIEW

 2-Methylnaphthoquinone is a synthetic chemical compound sometimes used as a nutritional supplement because of its vitamin K activity. It is an analog of 1,4-naphthoquinone with a methyl group in the 2-position, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo. 2-Methylnaphthoquinone is used in the treatment of Hypoprothrombinemia outside of the United States.

REFERENCES
[1]Kidd Parris M. Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. Alternative medicine review: a Journal of Clinical Therapeutic (2010) 15(3): 199-222.
[2] Kumagai, Yoshito; Shinkai, Yasuhiro; Miura, Takashi; Cho, Arthur K. The chemical biology of naphthoquinones and its environmental implications. Annual Review of Pharmacology and Toxicology. (2012) 52: 221-247.
[3] Lovern, Douglas; Marbois, Beth. Does menaquinone participate in brain astrocyte electron transport? Medical Hypotheses. (2013) 81(4): 587-591.
[4] Azizov, U. M.; Leont'eva, L. I.Methods for preparing 2-methyl-1,4-naphthoquinone (a review) Khimiko-Farmatsevticheskii Zhurnal (1989), 23(12), 1488-93.
[5] Wang, Shoukai Advances and synthetic technology of vitamin K3--feed additives Guangdong Huagong (1999), (2), 83-87.
[6] Kowalski, Jan; Ploszynska, Jolanta; Sobkowiak, Andrzej Methods for synthesis of vitamin K3 Wiadomosci Chemiczne (1999), 53(5-6), 401-413.
[7] Daines, Alison M.; Payne, Richard J.; Humphries, Mark E.; Abell, Andrew D.The synthesis of naturally occurring vitamin K and vitamin K analogues Current Organic Chemistry (2003), 7(16), 1625-1634.
[8] Moeller, Konstanze; Wienhoefer, Gerrit; Westerhaus, Felix; Junge, Kathrin; Beller, Matthias Oxidation of 1,2,4-trimethylbenzene (TMB), 2,3,6-trimethylphenol (TMP) and 2-methylnaphthalene to 2,3,5-trimethylbenzoquinone (TMBQ) and menadione (vitamin K3) Catalysis Today (2011), 173(1), 68-75.
[9] Lamson Davis W; Plaza Steven M The anticancer effects of vitamin K Alternative medicine review : a journal of clinical therapeutic (2003), 8(3), 303-18.
[10] Hassan GS. Menadione. Profiles Drug Subst Excip Relat Methodol. 2013;38:227-313.

Risk Description(s)
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.



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CATEGORIES

 APIs and Bioactives > Vitamins

USEFUL LINKS

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