H538 Cyclophosphamide monohydrate - AK Scientific
 
 
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  Catalog ID # H538
Cyclophosphamide monohydrate
, 98%
 
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide




IDENTITY
CAS Registry #:[6055-19-2]
MDL Number:MFCD00149395
MF:C7H15Cl2N2O2P.H2O
MW:279.1012
EINECS:200-015-4
BRN:8167897
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white crystals
Melting Point:49-53°C
Flash Point:113°C
Long-Term Storage:Store at 2-8°C
Shipping:Normal Temperature

REVIEW

 Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

REFERENCES
[1]Brock N: The history of the oxazaphosphorine cytostatics. Cancer. 1996 Aug 1;78(3):542-7.
[2] Brock N: Oxazaphosphorine cytostatics: past-present-future. Seventh Cain Memorial Award lecture. Cancer Res. 1989 Jan 1;49(1):1-7.

Risk Description(s)
R45:May cause cancer.
R25:Toxic if swallowed.

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  @PubChem  @Wikipedia