H539 Dacarbazine - AK Scientific
 
 
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  Catalog ID # H539
Dacarbazine
, 98% (HPLC)
 
DTIC
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
Dacatic
Deticene




IDENTITY
CAS Registry #:[4342-03-4]
MDL Number:MFCD00057167
MF:C6H10N6O
MW:182.1832
EINECS:224-396-1
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white to light yellow powder
Melting Point:207-212°C
Long-Term Storage:Store at -20°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):DNA Synthesis
Form:Free Base

REVIEW

 An antineoplastic chemotherapy drug used in the treatment of various cancers. Dacarbazine is a member of the class of alkylating agents that destroy cancer cells by adding an alkyl group (CnH2n+1) to its DNA.

REFERENCES
[1]Margolin K (2012). BRAF inhibition and beyond in advanced melanoma. Lancet. 380(9839):320-2. PMID 22735383.
[2] Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, Mart

Risk Description(s)
R45:May cause cancer.
R46:May cause heritable genetic damage.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  @PubChem  @Wikipedia