REVIEW Y-25130 Hydrochloride is a potent and selective SR-3 antagonist. This product was demonstrated to be an antiemetic agent valuable for countering adverse effects seen in anticancer therapy including cisplatin. In studies involving rat hippocampal slices, Y-25130 exhibited dose-dependent neuroprotective effects against an ischemia-induced decrease in CA1 field potential. It has also been reported to attenuate the cocaine-induced decrease of intracranial self-stimulation (ICSS) reward thresholds in rats. Other results of the SR-3 antagonistic activity of Y-25130 led to the acceleration of gastric emptying in mice.
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