H746 Esmolol HCl - AK Scientific
 
 
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  Catalog ID # H746
Esmolol HCl
, 98%
 
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride




IDENTITY
CAS Registry #:[81161-17-3]
MDL Number:MFCD00941432
MF:C16H25NO4.HCl
MW:331.8349
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White or almost white crystalline powder
Melting Point:85-86 °C
Long-Term Storage:keep 2-8°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:H2O: 12 mg/mL
Application(s):beta1 Receptor blocker
Form:HCl salt

REVIEW

 Similar to other beta-blockers, esmolol blocks the agonistic effect of the sympathetic neurotransmitters by competing for receptor binding sites. Because it predominantly blocks the beta-1 receptors in cardiac tissue, it is said to be cardioselective. In general, so-called cardioselective beta-blockers are relatively cardioselective; at lower doses they block beta-1 receptors only but begin to block beta-2 receptors as the dose increases. At therapeutic dosages, esmolol does not have intrinsic sympathomimetic activity (ISA) or membrane-stabilizing (quinidine-like) activity. Antiarrhythmic activity is due to blockade of adrenergic stimulation of cardiac pacemaker potentials. In the Vaughan Williams classification of antiarrhythmics, beta-blockers are considered to be class II agents.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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RELATED PRODUCTS
H746Esmolol HCl
K444Esmolol

CATEGORIES

 APIs and Bioactives > Beta Blockers

USEFUL LINKS

  PubChem