H751 2-Mercaptoethanesulfonic acid sodium salt - AK Scientific
 
 
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  Catalog ID # H751
2-Mercaptoethanesulfonic acid sodium salt
, 95%
 
Sodium 2-mercaptoethanesulfonate
Coenzyme M sodium salt
Uromitexan
Mesnex
Mesna




IDENTITY
CAS Registry #:[19767-45-4]
MDL Number:MFCD00007535
MF:C2H5O3S2.Na
MW:164.1791
EINECS:243-285-9
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to light yellow powder
Melting Point:259-275°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: 33mg/mL; H2O: 7mg/mL; EtOH: <1mg/mL
Application(s):Hemorrhagic cystitis inhibitor
Form:Free Base

REVIEW

 An organosulfur compound used in cancer chemotherapy involving cyclophosphamide and ifosfamide as an adjuvant. Mesna is used therapeutically to reduce the incidence of haemorrhagic cystitis and haematuria when a patient receives ifosfamide or cyclophosphamide for cancer chemotherapy.

REFERENCES
[1]Vepachedu VR, Ferry JG (2012). Role of the fused corrinoid/methyl transfer protein CmtA during CO-dependent growth of Methanosarcina acetivorans. J Bacteriol. 194(16):4161-8. PMID 22636775.
[2] Cutler MJ, Urquhart BL, Velenosi TJ, Meyer Zu Schwabedissen HE, Dresser GK, Leake BF, Tirona RG, Kim RB, Freeman DJ (2012). In vitro and in vivo assessment of renal drug transporters in the disposition of mesna and dimesna. J Clin Pharmacol. 52(4):530-42. PMID 21505084.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.



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CATEGORIES

 APIs and Bioactives > Chemotherapeutics, Mucokinetics

USEFUL LINKS

  @PubChem  @Wikipedia