H789 Procaine HCl - AK Scientific
 
 
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  Catalog ID # H789
Procaine HCl
, 98% (HPLC)
 
4-Aminobenzoic acid 2-(diethylamino)ethyl ester hydrochloride
2-(Diethylamino)ethyl 4-aminobenzoate hydrochloride
Novocaine hydrochloride




IDENTITY
CAS Registry #:[51-05-8]
MDL Number:MFCD00013000
MF:C13H20N2O2.HCl
MW:272.771
EINECS:200-077-2
BRN:3917802
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:153-158°C
Boiling Point:195-196°C (17mmHg)
Long-Term Storage:Store long-term at 2-8°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Form:HCl salt

REVIEW

 Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.

REFERENCES
[1]Gentry CL, Lukas RJ: Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48.

Risk Description(s)
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin
R43:May cause sensitization by skin contact.

Safety Description(s)
S20:When using do not eat or drink.
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
S60:This material and its container must be disposed of as hazardous waste.



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CATEGORIES

 APIs and Bioactives > Anaesthetics

USEFUL LINKS

  PubChem