H877 Melphalan - AK Scientific
 
 
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  Catalog ID # H877
Melphalan
, 98%
 
4-[Bis(2-chloroethyl)amino]-L-phenylalanine




IDENTITY
CAS Registry #:[148-82-3]
MDL Number:MFCD00057717
MF:C13H18Cl2N2O2
MW:305.2002
EINECS:205-726-3
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to cream to yellow powder
Melting Point:170-186°C
Optical Rotation:+5.4° (c=1.33, 1N HCl)
Shipping:Normal Temperature

REVIEW

 Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases (primarily at the N-7 position of guanine and to a lesser extent, at the N-3 position of adenine), forming monoadducts and resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

REFERENCES
[1]Loeber R, Michaelson E, Fang Q, Campbell C, Pegg AE, Tretyakova N: Cross-linking of the DNA repair protein Omicron6-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards. Chem Res Toxicol. 2008 Apr;21(4):787-95. Epub 2008 Feb 14.
[2] Souliotis VL, Dimopoulos MA, Episkopou HG, Kyrtopoulos SA, Sfikakis PP: Preferential in vivo DNA repair of melphalan-induced damage in human genes is greatly affected by the local chromatin structure. DNA Repair (Amst). 2006 Aug 13;5(8):972-85. Epub 2006 Jun 15.
[3] Moscow JA, Swanson CA, Cowan KH: Decreased melphalan accumulation in a human breast cancer cell line selected for resistance to melphalan. Br J Cancer. 1993 Oct;68(4):732-7.

Risk Description(s)
R45:May cause cancer.
R46:May cause heritable genetic damage.
R63:Possible risk of harm to the unborn child.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  @PubChem  @Wikipedia