H890 Cyclosporin A - AK Scientific
 
 
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  Catalog ID # H890
Cyclosporin A
, 98% (HPLC)
 
Cyclosporine
Antibiotic S 7481F1




IDENTITY
CAS Registry #:[59865-13-3]
MDL Number:MFCD00274558
MF:C62H111N11O12
MW:1202.6112
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:148-157°C
Optical Rotation:-189.0° - -196.0° (c=0.5, MeOH)
Long-Term Storage:Store at 2-8°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:Soluble in MeOH, EtOH, acetone, ether, CHCl3; slightly soluble in water and saturated hydrocarbons.
Application(s):Immunosuppressant agent

REVIEW

 Cyclosporine binds to cyclophilin. The complex then inhibits calcineurin which is normally responsible for activating transcription of interleukin 2. Cyclosporine also inhibits lymphokine production and interleukin release. In ophthalmic applications, the precise mechanism of action is not known. Cyclosporine emulsion is thought to act as a partial immunomodulator in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.

REFERENCES
[1]Lichtiger S, Present DH, Kornbluth A, Gelernt I, Bauer J, Galler G, Michelassi F, Hanauer S: Cyclosporine in severe ulcerative colitis refractory to steroid therapy. N Engl J Med. 1994 Jun 30;330(26):1841-5.

Risk Description(s)
R45:May cause cancer.
R60:May impair fertility.
R22:Harmful if swallowed.

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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RELATED PRODUCTS
H890Cyclosporin A
Q333Cyclosporine

CATEGORIES

 APIs and Bioactives > Immunomodulators
 Amino Acids > Peptides

USEFUL LINKS

  PubChem