95058-81-4 Gemcitabine AKSci J10023
 
 
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  J10023    
Gemcitabine, 99% (HPLC), powder
 
Gemzar
2''-Deoxy-2'',2''-difluorocytidine
IDENTITY
CAS Number:95058-81-4
MDL Number:MFCD00869720
MF:C9H11F2N3O4
MW:263.2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:200-229°C
Optical Rotation:+65° to 71° (c=1, MeOH)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 15mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Antimetabolite; Enzyme Inhibitor; Immunosuppressive Agent; Radiation-Sensitizing Agent; Ribonucleoti
Form:Free Base

REVIEW
 An antineoplastic agent and antimetabolite. Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.

REFERENCES
[1]Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB (2012). Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer. 131(3):E292-303. PMID 21935918.
[2] Kobayashi H, Murakami Y, Uemura K, Sudo T, Hashimoto Y, Kondo N, Sueda T (2012). Human equilibrative nucleoside transporter 1 expression predicts survival of advanced cholangiocarcinoma patients treated with gemcitabine-based adjuvant chemotherapy after surgical resection. Ann Surg. 256(2):288-96. PMID 22580938.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501

RELATED PRODUCTS
F287Gemcitabine hydrochloride
K723Gemcitabine

Current as of April 25, 2024


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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