25812-30-0 Gemfibrozil AKSci J10068
 
 
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  J10068    
Gemfibrozil, >98% (GC), powder
 
2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeric acid
Lopid
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IDENTITY
CAS Number:25812-30-0
MDL Number:MFCD00079335
MF:C15H22O3
MW:250.33
EINECS:247-280-2
BRN:1881200
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (GC), powder
Physical Form (at 20°C):Solid
Melting Point:58-63°C
Boiling Point:158-159°C (0.02mmHg)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 50mg/mL; H2O: <1mg/mL; EtOH: 50mg/mL
Application(s):Peroxisome proliferator-activated receptor-alpha (PPARa) agonist
Form:Free Base

REVIEW
 Gemfibrozil is an oral drug used to lower lipid levels, which is an activator of Peroxisome proliferator-activated receptor-alpha (PPARa), a nuclear receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides.

REFERENCES
[1]Corbett GT, Roy A, Pahan K (2012). Gemfibrozil, a lipid-lowering drug, upregulates IL-1 receptor antagonist in mouse cortical neurons: implications for neuronal self-defense. J Immunol. 189(2):1002-13. PMID 22706077.
[2] Bulloch DN, Lavado R, Forsgren KL, Beni S, Schlenk D, Larive CK (2012). Analytical and biological characterization of halogenated gemfibrozil produced through chlorination of wastewater. Environ Sci Technol. 46(10):5583-9. PMID 22494162.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of April 18, 2024


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Gemfibrozil, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Hypercholesterolemia, Fibrates


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