1397-89-3 Amphotericin B AKSci J10140
 
 
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  J10140    AKSci Reference Standard
Amphotericin B, 85% (HPLC)
 
Amphotericin
Ambisome
Fungilin
more..
IDENTITY
CAS Number:1397-89-3
MDL Number:MFCD00877763
MF:C47H73NO17
MW:924.079
EINECS:215-742-2
BRN:78342
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:85% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>350°C
Density:1.34
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Insoluble in water

REVIEW
 Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

REFERENCES
[1]Khan N, Rawlings B, Caffrey P (2011-01-26). A labile point in mutant amphotericin polyketide synthases. Biotechnol Lett. 33 (6): 1121-6. doi:10.1007/s10529-011-0538-3. PMID 21267757.
[2] Kafetzis DA, Velissariou IM, Stabouli S, Mavrikou M, Delis D, Liapi G (January 2005). Treatment of paediatric visceral leishmaniasis: amphotericin B or pentavalent antimony compounds?. Int. J. Antimicrob. Agents 25 (1): 26-30. doi:10.1016/j.ijantimicag.2004.09.011. PMID 15620822.
[3] Veerareddy PR, Vobalaboina V, Ali N (December 2008). Antileishmanial activity, pharmacokinetics and tissue distribution studies of mannose-grafted amphotericin B lipid nanospheres. J Drug Target 17 (2): 140-7. doi:10.1080/10611860802528833. PMID 19089691.
[4] Baginski, M.; Czub, J. (2009). Amphotericin B and Its New Derivatives-Mode of Action. Current Drug Metabolism 10 (5): 459-69. PMID 19689243.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Fungicides


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