298-81-7 Xanthotoxin AKSci J10204
 
 
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  J10204    AKSci Reference Standard
Xanthotoxin, 99% (HPLC), powder
 
8-Methoxypsoralen, Methoxsalen
IDENTITY
CAS Number:298-81-7
MDL Number:MFCD00005009
MF:C12H8O4
MW:216.19
EINECS:206-066-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:143-148°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:Free base
Research Area:Inflammation

REVIEW
 Methoxsalen (also called xanthotoxin), a furanocoumarin, is marketed under the trade names of Oxsoralen, Deltasoralen, Meladinine to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to long wavelength UV light from lamps or sunlight (photochemotherapy). Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease, by the formation of psoralen DNA photoadducts. More recently it has been found that methoxsalen and ultraviolet A light (UVA) has been reported to modulate cytokine production via a Th1-skewing cytokine modifier and that methoxsalen -phototreated CD4+ T cells allow monocytes to become effective tumor antigen-presenting cells for tumor-specific cytotoxic T cells.

REFERENCES
[1]Musajo L, Rodighiero G. Mode of photosensitizing action of furocoumarins. Photophysiology. 1972;(7):115-47.
[2] Parrish JA, LeVine MJ, Fitzpatrick TB, Oral methoxsalen photochemotherapy of psoriasis and mycosis fungoides. Int J Dermatol. 1980 Sep;19(7):379-86.
[3] Bond CA, Grant K, Boh L, Photochemotherapy of psoriasis with methoxsalen and longwave ultraviolet light (PUVA). Am J Hosp Pharm. 1981 Jul;38(7):990-5.
[4] Grossweiner LI. Mechanisms of photosensitization by furocoumarins Natl Cancer Inst Monogr. 1984 Dec;66:47-54.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H317

Precautionary Statements
P261; P264; P270; P272; P280; P301+P312; P302+P352; P321; P330; P333+P313; P363; P501

Current as of April 25, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Xanthotoxin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




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