56296-78-7 Fluoxetine hydrochloride AKSci J10277
 
 
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  J10277    
Fluoxetine hydrochloride, >99% (HPLC), powder
 



IDENTITY
CAS Number:56296-78-7
MDL Number:MFCD00214288
MF:C17H18F3NO.HCl
MW:345.79
EINECS:260-101-2
BRN:6759273
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:155-161°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >5mg/mL; H2O: 4mg/mL; EtOH: 69mg/mL
Application(s):Serotonin reuptake inhibitor (SSRI) inhibitor
Form:HCl salt

REVIEW
 Fluoxetine is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Fluoxetine''s mechanism of action is predominantly that of a serotonin reuptake inhibitor. Fluoxetine delays the reuptake of serotonin, resulting in serotonin persisting longer when it is released. Fluoxetine may also produce some of its effects via its potent 5-HT2C receptor antagonist effects. In addition, fluoxetine has been found to act as an agonist of the s1-receptor, with a potency greater than that of citalopram but less than that of fluvoxamine. However, the significance of this property is not fully clear.

REFERENCES
[1]Fuller RW, Perry KW, Molloy BB (1974). Effect of an uptake inhibitor on serotonin metabolism in rat brain: studies with 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine (Lilly 110140). Life Sciences 15 (6): 1161-71. PMID 4550008.
[2] Tatsumi M, Groshan K, Blakely RD, Richelson E (1997). Pharmacological profile of antidepressants and related compounds at human monoamine transporters. European Journal of Pharmacology 340 (2-3): 249-58. PMID 9537821.
[3] Pälvimäki EP, Roth BL, Majasuo H, et al. (1996). Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor. Psychopharmacology 126 (3): 234-40. PMID 8876023.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H318; H410

Precautionary Statements
P264; P270; P273; P280; P301+P312; P305+P351+P338; P310; P330; P391; P501

Current as of April 23, 2024


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CATEGORIES
 APIs and Bioactives > Antidepressants


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