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BIOLOGICAL INFO
Solubility:
DMSO: 3mg/mL; H2O: <1mg/mL; EtOH: 4mg/mL
Application(s):
serotonin-dopamine antagonist
Form:
Free Base
REVIEW Risperidone is an atypical antipsychotic drug mainly used to treat schizophrenia, schizoaffective disorder, bipolar disorder, and irritability in people with autism. It is a dopamine antagonist possessing antiserotonergic, antiadrenergic and antihistaminergic properties.
REFERENCES
[1]
Kennis, Ludo Edmond Josephine; Vandenberk, Jan Preparation of 1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives as antipsychotics. Eur. Pat. Appl. (1986), EP 196132 A2 19861001.
[2]
Marquillas Olondriz, Francisco; Bosch Rovira, Anna; Dalmases Barjoan, Pere; Caldero Ges, Jose Maria Process for preparation of 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one [risperidone] Span. (1994), ES 2050069 A1 19940501.
[3]
Norman M H; Navas F 3rd; Thompson J B; Rigdon G C Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents Journal of medicinal chemistry (1996), 39(24), 4692-703.
[4]
Cai HL, Li HD, Yan XZ, Sun B, Zhang Q, Yan M, Zhang WY, Jiang P, Zhu RH, Liu YP, Fang PF, Xu P, Yuan HY, Zhang XH, Hu L, Yang W, Ye HS (2012). Metabolomic analysis of biochemical changes in the plasma and urine of first-episode neuroleptic-naïve schizophrenia patients after treatment with risperidone. J Proteome Res. 3;11(8):4338-50. PMID 22800120.
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