49562-28-9 Fenofibrate AKSci J10318
 
 
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  J10318    
Fenofibrate, 99% (HPLC), powder
 
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
Isopropyl 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionate
Antara
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IDENTITY
CAS Number:49562-28-9
MDL Number:MFCD00133314
MF:C20H21ClO4
MW:360.83
EINECS:256-376-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:79-86°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 72mg/mL; H2O: <1mg/mL; EtOH: 46mg/mL
Application(s):Peroxisome proliferator-activated receptor alpha (PPARa) agonist
Form:Free Base

REVIEW
 Fenofibrate is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. Like other fibrates, it reduces both low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) levels, as well as increasing high-density lipoprotein (HDL) levels and reducing triglycerides level. The drug lowers lipid levels by activating Peroxisome proliferator-activated receptor alpha (PPARa). PPARa activates lipoprotein lipase and reduces apoprotein CIII, which increases lipolysis and elimination of triglyceride-rich particles from plasma.

REFERENCES
[1]Wilk A, Urbanska K, Grabacka M, Mullinax J, Marcinkiewicz C, Impastato D, Estrada JJ, Reiss K (2012). Fenofibrate-induced nuclear translocation of FoxO3A triggers Bim-mediated apoptosis in glioblastoma cells in vitro. Cell Cycle. 11(14):2660-71. PMID 22732497.
[2] Patel A, Macwana C, Parmar V, Patel S (2012). Simultaneous determination of atorvastatin calcium, ezetimibe, and fenofibrate in a tablet formulation by HPLC. J AOAC Int. 95(2):419-23. PMID 22649929.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Hypercholesterolemia, Fibrates


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