1134-47-0 Baclofen AKSci J10366
 
 
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  J10366    AKSci Reference Standard
Baclofen, >98% (HPLC), powder
 
(+/-)-beta-(Aminomethyl)-4-chlorobenzenepropanoic acid
Lioresal
IDENTITY
CAS Number:1134-47-0
MDL Number:MFCD00055143
MF:C10H12ClNO2
MW:213.66
EINECS:214-486-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:201-208°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:1M HCl: 50mg/ml
Application(s):Gamma-amino-butyric acid (GABA) derivative

REVIEW
 Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.

REFERENCES
[1]Dzitoyeva S, Dimitrijevic N, Manev H: Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11.
[2] Mezler M, Muller T, Raming K: Cloning and functional expression of GABA receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86.
[3] See S, Ginzburg R: Skeletal muscle relaxants. Pharmacotherapy. 2008 Feb;28(2):207-13.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H315; H317; H319; H334; H335; H360

Precautionary Statements
P201; P202; P261; P264; P270; P271; P272; P280; P301+P310; P302+P352; P304+P340; P305+P351+P338; P308+P313; P321; P330; P333+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 23, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Alcoholism


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