54965-21-8 Albendazole AKSci J10424
 
 
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  J10424    
Albendazole, >98% (HPLC)
 
Methyl 5-(propylthio)-2-benzimidazolecarbamate
Albenza
Andazol
more..
IDENTITY
CAS Number:54965-21-8
MDL Number:MFCD00083232
MF:C12H15N3O2S
MW:265.33
EINECS:259-414-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:206-210°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 25mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Tubulin Modulator
Form:Free Base

REVIEW
 A member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.

REFERENCES
[1]Speich B, Ame SM, Ali SM, Alles R, Hattendorf J, Utzinger J, Albonico M, Keiser J (2012). Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial. PLoS Negl Trop Dis. 6(6):e1685. PMID 22679525.
[2] Küster T, Zumkehr B, Hermann C, Theurillat R, Thormann W, Gottstein B, Hemphill A (2012). Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice. J Am Assoc Lab Anim Sci. 51(2):219-23. PMID 22776122.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H361; H373

Precautionary Statements
P201; P202; P260; P281; P308+P313; P405; P501

Current as of April 19, 2024


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CATEGORIES
 APIs and Bioactives > Antiparasitics


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