22161-81-5 (S)-(+)-Ketoprofen AKSci J10911
 
 
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  J10911    AKSci Reference Standard
(S)-(+)-Ketoprofen, >99% (GC); ee: >99% (Chiral SFC)
 
(S)-(+)-3-Benzoyl-a-methylbenzeneacetic acid
(S)-2-(3-Benzoylphenyl)propionic acid
IDENTITY
CAS Number:22161-81-5
MDL Number:MFCD00673316
MF:C16H14O3
MW:254.28
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (GC); ee: >99% (Chiral SFC)
Physical Form (at 20°C):Solid
Melting Point:75-78°C
Optical Rotation:+49° (c=1, MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Application(s):Nonsteroidal anti-inflammatory agent (NSAIA)

REVIEW
 The anti-inflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase-2 (COX-2), an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins that mediate pain, fever and inflammation. Ketoprofen is a non-specific cyclooxygenase inhibitor and inhibition of COX-1 is thought to confer some of its side effects, such as GI upset and ulceration. Ketoprofen is thought to have anti-bradykinin activity, as well as lysosomal membrane-stabilizing action. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation.

REFERENCES
[1]Kantor TG: Ketoprofen: a review of its pharmacologic and clinical properties. Pharmacotherapy. 1986 May-Jun;6(3):93-103.
[2] Mazieres B: Topical ketoprofen patch. Drugs R D. 2005;6(6):337-44.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H315; H319; H335; H410

Precautionary Statements
P261; P264; P270; P271; P273; P280; P301+P310; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P391; P403+P233; P405; P501

RELATED PRODUCTS
F498Ketoprofen
V1301(S)-(+)-Ketoprofen

Current as of April 20, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > NSAIDs


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