96829-58-2 Orlistat AKSci J90006
 
 
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  J90006    AKSci Bulk Reagent
Orlistat, 95%
 
Tetrahydrolipstatin
N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester
(2S)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate
IDENTITY
CAS Number:96829-58-2
MDL Number:MFCD05662360
MF:C29H53NO5
MW:495.73
BRN:3658031
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:42-47°C
Optical Rotation:-33 - -36° (c=1, CHCl3)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 99mg/mL; H2O: <1mg/mL; EtOH: 99mg/mL
Application(s):Lipase inhibitor
Form:Free base

REVIEW
 Orlistat is a drug designed to treat obesity. Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead.

REFERENCES
[1]Smith TJ, Crombie A, Sanders LF, Sigrist LD, Bathalon GP, McGraw S, Young AJ (2012). Efficacy of orlistat 60 mg on weight loss and body fat mass in US Army soldiers. J Acad Nutr Diet. 112(4):533-40. PMID 22717217.
[2] Gelebart P, Zak Z, Anand M, Belch A, Lai R (2012). Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. PLoS One. 7(4):e33738. PMID 22485149.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Weight Control


PubChem