REVIEW Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Cancer cells rely on this enzyme more than healthy cells, since they divide more rapidly. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.
REFERENCES
[1]
Hande, K. R. (1998). Etoposide: Four decades of development of a topoisomerase II inhibitor. European Journal of Cancer 34 (10): 1514-1521. doi:10.1016/S0959-8049(98)00228-7. PMID 9893622.
[2]
Gordaliza M, García PA, del Corral JM, Castro MA, Gómez-Zurita MA (2004). Podophyllotoxin: distribution, sources, applications and new cytotoxic derivatives. Toxicon 44 (4): 441-59. doi:10.1016/j.toxicon.2004.05.008. PMID 15302526.
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