K077 Diisopropylammonium dichloroacetate - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # K077
Diisopropylammonium dichloroacetate
, 95%
 
Vasculopatina
Dipromonium
Cubisol
Dapocel
Disotat
Kalodil
Oxypangam
Tensicor
Dedyl
Diisopropylamine dichloroacetate




IDENTITY
CAS Registry #:[660-27-5]
MDL Number:MFCD00868288
MF:C6H15N.C2H2Cl2O2
MW:230.1321
EINECS:211-538-2
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White crystalline powder
Shipping:Normal Temperature

REVIEW

 Diisopropylammonium dichloroacetate is a vasodilator, and the active principle of pangamic acid. It has also been found to exert a significant and prolonged hypoglycemic effect in alloxan diabetic rats, but did not alter blood sugar levels of normal rats. It did not affect blood glycerol levels in either the diabetic or nondiabetic group. By suppressing fatty acid oxidation in muscle, it may reduce citrate levels and reactivate phosphofructokinase.

REFERENCES
[1]Santi, R.; Contessa, A. R.; Cozzari, L. Vantaggi. Pharmacologic action of diisopropylammonium dichloroacetate. Minerva Medica. (1960) 51: 2909-19.
[2] Stacpoole PW, Felts JM. Diisopropylammonium dichloroacetate (DIPA) and sodium dichloracetate (DCA): effect on glucose and fat metabolism in normal and diabetic tissue. Metabolism. (1970) Jan;19(1): 71-8.
[3] Kitamura N; Ota Y; Mimura K. Effects of diisopropylamine dichloroacetate on proliferation and differentiation of normal human keratinocytes in vitro. Skin Pharmacology and Applied Skin Physiology (1999) 12(6): 317-25.
[4] Diisopropylammonium salts (1958), DE 1105877 19580804.
[5] Bertelli, A.; Casentini, S.Dichloroacetate of diisopropylammonium as the molecule responsible for some pharmacological activity attributed to pangamic acid Bollettino - Societa Italiana di Biologia Sperimentale (1958), 34, 1532-4
[6] Diisopropylammonium salts of chloroacetic and chloropropionic acids (1961), GB 862248 19610308
[7] Stacpoole PW, Iwamoto E, Glasgow CE. Diisopropylammonium dichloroacetate (DIPA): reversible antagonism towards smooth muscle stimulants and inhibition of acetylcholinesterase in the isolated guinea pig ileum. Res Commun Chem Pathol Pharmacol. 1971 Jul-Sep;2(4):439-46
[8] Schneider D, Helwig V, Staniek K, Nohl H, Elstner EF. Studies on the chemical identity and biological functions of pangamic acid. Arzneimittelforschung. 1999 Apr;49(4):335-43.

Risk Description(s)
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S60:This material and its container must be disposed of as hazardous waste.



Pricing (not showing? please refresh your web browser)

CATEGORIES

 APIs and Bioactives >

USEFUL LINKS

  PubChem