M047 beta-Sitosterol, Technical grade - AK Scientific
 
 
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  Catalog ID # M047
beta-Sitosterol, Technical grade
, ~70%
 
alpha-Dihydrofucosterol
22,23-Dihydrostigmasterol
24beta-Ethylcholesterol
5-Stigmasten-3beta-ol




IDENTITY
CAS Registry #:[83-46-5]
MDL Number:MFCD00003631
MF:C29H50O
MW:414.7067
EINECS:201-480-6
BRN:1916165
SPECIFICATIONS & PROPERTIES
Purity:~70%
Grade:Technical grade
Physical Form:White to beige crystalline powder
Melting Point:136-142°C
Optical Rotation:-33° - -39° (c=0.5, CHCl3)
Long-Term Storage:Store long-term at -20°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Application(s):Phytosterols

REVIEW

 Beta-Sitosterol is one of several phytosterols related to cholesterol. It reduces blood levels of cholesterol by competing with it for absorption in the intestine and is sometimes used in treating hypercholesterolemia. Due to its structural similarity to cholesterol, when sitosterol is absorbed in the intestine, it is transported by lipoproteins and incorporated into the cellular membrane. It takes the place of dietary and biliary cholesterol in micelles produced in the intestinal lumen.

REFERENCES
[1]Geoffroy, Philippe; Julien-David, Diane; Marchioni, Eric; Raul, Francis; Aoude-Werner, Dalal; Miesch, Michel Synthesis of highly pure oxyphytosterols and (oxy)phytosterol esters Steroids (2008), 73(7), 702-707.
[2] Hang, Jiliang; Dussault, Patrick A concise synthesis of beta-sitosterol and other phytosterols Steroids (2010), 75(12), 879-883.
[3] Berges RR, Windeler J, Trampisch HJ, Senge T. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Beta-sitosterol Study Group. Lancet. 1995 Jun 17;345(8964):1529-32.
[4] Wilt TJ, MacDonald R, Ishani A.beta-sitosterol for the treatment of benign prostatic hyperplasia: a systematic review. BJU Int. 1999 Jun;83(9):976-83.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Hypercholesterolemia

USEFUL LINKS

  PubChem