M363 Dorzolamide HCl - AK Scientific
 
 
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  Catalog ID # M363
Dorzolamide HCl
, 98% (HPLC)
 
Trusopt
Cosopt
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride




IDENTITY
CAS Registry #:[130693-82-2]
MDL Number:MFCD00884659
MF:C10H16N2O4S3.HCl
MW:360.901
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White to off-white crystalline powder
Melting Point:283-285 °C
Optical Rotation:-8° (c=1,MeOH)
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 14mg/mL; EtOH: <1mg/mL
Application(s):Carbonic anhydrase inhibitor
Form:HCl salt

REVIEW

 A carbonic anhydrase inhibitor. The drug is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

REFERENCES
[1]Mincione F, Starnotti M, Masini E, Bacciottini L, Scrivanti C, Casini A, Vullo D, Scozzafava A, Supuran CT (2005). Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett. 15(17):3821-7. PMID 16039853.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Ophthalmology, Carbonic Anhydrase Inhibitors

USEFUL LINKS

  PubChem