N025 Yohimbine HCl - AK Scientific
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  Catalog ID # N025
Yohimbine HCl
, 99% (HPLC)
17-Hydroxyyohimban-16-carboxylic acid methyl ester hydrochloride

CAS Registry #:[65-19-0]
MDL Number:MFCD00012674
Purity:99% (HPLC)
Physical Form:White to off-white crystalline powder
Melting Point:273-301°C
Optical Rotation:+99 °(c=1, H2O)
Shipping:Normal Temperature
UN #:1544
Hazard Class:6.1
Packing Group:II

Solubility:H2O: 10mg/mL; Soluble to 25 mM in DMSO
Application(s):Sympatholytic agent


 Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. Yohimbine-mediated norepinephrine release at the level of the corporeal tissues may also be involved. In addition, beneficial effects may involve other neurotransmitters such as dopamine and serotonin and cholinergic receptors.

[1]Rosengren, A. H.; Jokubka, R.; Tojjar, D.; Granhall, C.; Hansson, O.; Li, D.-Q.; Nagaraj, V.; Reinbothe, T. M. et al. (2009). "Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes". Science 327 (5962): 217-20. doi:10.1126/science.1176827. PMID 19965390.
[2] Saenz De Tejada, I; Kim, NN; Goldstein, I; Traish, AM (2000). "Regulation of pre-synaptic alpha adrenergic activity in the corpus cavernosum". International Journal of Impotence Research 12 Suppl 1: S20-25. doi:10.1038/sj.ijir.3900500. PMID 10845761.

Risk Description(s)
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

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*For reference only. Please do not use in place of local hazmat regulations.

*CURRENT AS OF: March 6, 2015
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 APIs and Bioactives > Alkaloids