442847-66-7 Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone HCl AKSci O189
 
 
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  O189    
Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone HCl, 98%
 
Thienamycin p-nitrobenzylester hydrochloride
4-Nitrobenzyl (5R,6S)-3-[(2-aminoethyl)sulfanyl]-6-[(1R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate - 1-methyl-2-pyrrolidinone hydrochloride
IDENTITY
CAS Number:442847-66-7
MDL Number:MFCD20922853
MF:C18H21N3O6S.C5H9NO.HCl
MW:543.03
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:133-138°C
Density:1.49
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:HCl salt

REVIEW
 Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone is a carbapenem intermediate use in the preparation of the carbopenem antibiotic, imipenem.

REFERENCES
[1]Zenoni, Maurizio; Camozzi, Manuel; Maschio, Process for preparation of imipenem from carbapenem analog , U.S. Pat. Appl. Publ. (2002), US 20020095034 A1 20020718.
[2] Panchapakesan, Ganpathy; Arumugam, Nagappan; Sudhan, Henry Syril Improved process for the preparation of the carbapenem antibiotic imipenem Indian Pat. Appl. (2007), IN 2005CH01178 A 20070727.
[3] Udayampalayam Palanisamy, Senthilkumar; Gnanaprakasam, Andrew; Ganapathy, Veeramani; Kanagaraj, Sureshkumar; Singaravel, Mohan An improved process for the preparation of imipenem PCT Int. Appl. (2010), WO 2010146449 A1 20101223.
[4] Gnanaprakasam, Andrew; Ganapathy, Veeramani; Sekar, Jeyaraj; Arulmoli, Thangavel A process for the preparation of pure crystalline imipenem monohydrate Indian Pat. Appl. (2012), IN 2010CH03462 A 20121116.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
O189Thienamycin p-nitrobenzyl ester, N-methylpyrrolidinone HCl
V0218Protected thiencin hydrochloride

Current as of April 16, 2024


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CATEGORIES
 APIs and Bioactives > Antibacterials


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