(βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-Hexahydro-β,,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid monosodium salt, Pravastatin sodium salt
IDENTITY
CAS Number:
81131-70-6
MDL Number:
MFCD00887601
MF:
C23H35O7.Na
MW:
446.51
BRN:
4836204
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
171-175°C
Optical Rotation:
+153° ~ +160° (c=0.5, H2O)
Long-Term Storage:
Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
H2O: >10mg/mL
Application(s):
HMG-CoA reductase inhibitor
REVIEW Pravastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Unlike its parent compound, mevastatin, and statins such as lovastatin and simvastatin, pravastatin does not need to be activated in vivo. Its hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with a much greater affinity than its natural substrate. The bicyclic portion of pravastatin binds to the coenzyme A portion of the active site.
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WARNING: Attention California residents: This product can expose you to chemicals including Pravastatin sodium, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.