O918 10-HDA - AK Scientific
 
 
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  Catalog ID # O918
10-HDA
, 98% (HPLC)
 
Royal Jelly acid
(E)-10-Hydroxy-2-decenoic acid
10-hydroxy-2-decenoic acid
Queen Bee Acid




IDENTITY
CAS Registry #:[14113-05-4]
MDL Number:MFCD00204506
MF:C10H18O3
MW:186.25
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:NMR, LCMS, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:61-65°C
Long-Term Storage:Store long-term at -20°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:Soluble in chloroform, ethanol, methanol
Application(s):An inhibitor of VEGF-induced angiogenesis, cell migration and proliferation

REVIEW

 10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 µM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 µM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 µM and 1.5 mM, respectively.

REFERENCES
[1]Kodai, T., Umebayashi, K., Nakatani, T., et al. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chem Pharm Bull 55(10) 1528-1531 (2007).
[2] Honda, Y., Fujita, Y., Maruyama, H., et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6(8) 1-10 (2011).
[3] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).
[4] Wang, J., Ruan, J., Li, C., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatol Int (2011).

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Natural Products

USEFUL LINKS

  PubChem