P087 Agmatine sulfate - AK Scientific
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  Catalog ID # P087
Agmatine sulfate
, 98%
1-Amino-4-guanidinobutane sulfate salt
4-Guanidinobutylamine sulfate salt
N-(4-Aminobutyl)guanidine sulfate salt

CAS Registry #:[2482-00-0]
MDL Number:MFCD00013109
Physical Form:White to off-white powder
Melting Point:234-238°C
Shipping:Normal Temperature

Solubility:H2O: 50mg/mL; EtOH: insoluble
Application(s):Nitric oxide synthase (NOS) inhibitor; NMDA-activated ion channels blocker
Form:Sulfate salt


 Agmatine sulfate is a natural metabolite salt of the amino acid arginine. It is formed when arginine is decarboxylated by the enzyme arginine decarboxylase and is found naturally. Some of the biochemical mechanisms discovered so far concern agmatine's indication for diabetes, neuroprotection, and psychiatric conditions.

[1]Su, Rui-Bin; Wang, Wei-Ping; Lu, Xin-Qiang; Wu, Ning; Liu, Zhi-Min; Li, Jin. Agmatine blocks acquisition and re-acquisition of intravenous morphine self-administration in rats. Pharmacology, Biochemistry and Behavior. (2009) 92(4): 676-682.
[2] Kotagale, Nandkishor Ramdas; Shirbhate, Saurabh Haridas; Shukla, Pradeep; Ugale, Rajesh Ramesh. Agmatine attenuates neuropathic pain in sciatic nerve ligated rats: Modulation by hippocampal sigma receptors. European Journal of Pharmacology. (2013) 714(1-3): 424-431.
[3] Kotagale, Nandkishor R.; Taksande, Brijesh G.; Wadhwani, Paresh J.; Palhade, Mahesh W.; Mendhi, Sachin M.; Gawande, Dinesh Y.; Hadole, Pravin N.; Chopde, Chandrabhan T. Psychopharmacological study of agmatine in behavioral tests of schizophrenia in rodents. Pharmacology, Biochemistry and Behavior. (2012) 100(3): 398-403.
[4] Golding, Bernard T.; Griffin, Roger J.; Mitchinson, Andrew; O'Sullivan, Mary C.New Routes to polyamine analogs Biochemical Society Transactions (1994), 22(4), 391S.
[5] Shoeb, S. M.; Kaneoke, M.; Shimizu, E.; Yorifuji, T.Diguanidinobutanase of Pseudomonas putida and enzymic preparation of agmatine from 1,4-diguanidinobutane Applied Microbiology and Biotechnology (1995), 44(1-2), 94-9.
[6] Ye, Shan-shan; Wang, Jian-wei; Shan, Wei-guang; Ye, Lu; Zou, Jian-feng Green process for the preparation of agmatine sulfate Zhejiang Huagong (2010), 41(9), 5-7.
[7] Shan, Weiguang; Ye, Shanshan; Wang, Jianwei; Zhan, Zajun; Tang, Lan; Hou, Xiaorong; Yu, Haining A method for preparing agmatine sulfate Faming Zhuanli Shenqing Gongkai Shuomingshu (2010), CN 101717352 A 20100602.
[8] Berenholz L, Segal S, Gilad VH, Klein C, Yehezkeli E, Eviatar E, Kessler A, Gilad GM. Agmatine treatment and vein graft reconstruction enhance recovery after experimental facial nerve injury. J Peripher Nerv Syst. 2005 Sep;10(3):319-28.
[9] Luszczki, Jarogniew J.; Czernecki, Remigiusz; Dudra-Jastrzebska, Monika; Borowicz, Kinga K.; Czuczwar, Stanislaw J.Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in miceA Pharmacological Reports (2009), 61(2), 252-260.
[10] Keynan O, Mirovsky Y, Dekel S, Gilad VH, Gilad GM.Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial. Pain Med. 2010 Mar;11(3):356-68
[11] Gul, Fethi; Pelit, Tuba; Terzioglu, Berna; Ekinci, Osman; Goren, M. Zafer Effects of agmatine on the survival rate in rats bled to hemorrhage Arzneimittel Forschung (2011), 61(4), 229-233.
[12] Utkan, Tijen; Gocmez, Semil S.; Regunathan, Soundararajan; Aricioglu, Feyza Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats Pharmacology, Biochemistry and Behavior (2012), 102(4), 578-584.
[13] Rushaidhi, M.; Zhang, H.; Liu, P.Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats Neuroscience (Amsterdam, Netherlands) (2013), 234, 116-124
[14] Gilad GM, Gilad VH.Evidence for oral agmatine sulfate safety--a 95-day high dosage pilot study with rats. Food Chem Toxicol. 2013 Dec;62:758-62

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.

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X3130Agmatine dihydrochloride
P087Agmatine sulfate


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