P087 Agmatine sulfate - AK Scientific
 
 
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  Catalog ID # P087
Agmatine sulfate
, 98%
 
1-Amino-4-guanidinobutane sulfate salt
4-Guanidinobutylamine sulfate salt
N-(4-Aminobutyl)guanidine sulfate salt




IDENTITY
CAS Registry #:[2482-00-0]
MDL Number:MFCD00013109
MF:C5H14N4.H2SO4
MW:228.27
EINECS:219-617-3
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white powder
Melting Point:234-238°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:H2O: 50mg/mL; EtOH: insoluble
Application(s):Nitric oxide synthase (NOS) inhibitor; NMDA-activated ion channels blocker
Form:Sulfate salt

REVIEW

 Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is discussed as a putative neurotransmitter. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase. Agmatine binds to a2-adrenergic receptor and imidazoline binding sites, and blocks NMDA receptors and other cation ligand-gated channels. Agmatine inhibits nitric oxide synthase (NOS), and it induces the release of some peptide hormones.

REFERENCES
[1]Thorn DA, Winter JC, Li JX (2012). Agmatine attenuates methamphetamine-induced conditioned place preference in rats. Eur J Pharmacol. 680(1-3):69-72. PMID 22329899.
[2] Tsai MF, Fang Y, Miller C (2012). Sided functions of an arginine-agmatine antiporter oriented in liposomes. Biochemistry. 51(8):1577-85. PMID 22304019.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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RELATED PRODUCTS
X3130Agmatine dihydrochloride
P087Agmatine sulfate

CATEGORIES

 APIs and Bioactives

USEFUL LINKS

  PubChem