U636 Bucladesine sodium - AK Scientific
 
 
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  Catalog ID # U636
Bucladesine sodium
, 95% (HPLC)
 
N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt
Dibutyl cyclic AMP sodium salt
Dibutyryl-cAMP




IDENTITY
CAS Registry #:[16980-89-5]
MDL Number:MFCD00005843
MF:C18H23N5O8P.Na
MW:491.3675
EINECS:241-059-4
SPECIFICATIONS & PROPERTIES
Purity:95% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White to off-white to beige powder
Long-Term Storage:Store at -20°C
Shipping:Normal Temperature
Note:Loses 2'-O-butyryl group at pH 8.5. Impurity: =3% N6-monobutyryl-cyclic AMP; =0.5% cyclic AMP and 2'-O-monobutyryl-cyclic AMP

BIOLOGICAL INFO
Solubility:H2O:100mg/mL; DMSO (200mM) or 96% ethanol (25mM).
Application(s):PKA activator; Phosphodiesterase inhibitor
Form:Sodium salt

REVIEW

 Bucladesine is a cyclic nucleotide derivative, mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. A cell-permeable cAMP analog which preferentially activates cAMP-dependent protein kinase. The products releaes butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 Nucleobases > Nucleotides
 APIs and Bioactives

USEFUL LINKS

  PubChem