V0098 (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone - AK Scientific
 
 
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  Catalog ID # V0098
(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone
, 98%
 



IDENTITY
CAS Registry #:[189028-93-1]
MDL Number:MFCD08061377
MF:C20H18FNO4
MW:355.36
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White crystalline powder
Melting Point:88-92°C
Shipping:Normal Temperature

REVIEW

 (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone is a key advanced intermediate used in the preparation of ezetimibe.

REFERENCES
[1]Thiruvengadam, Tiruvettipuram K.; Fu, Xiaoyong; Tann, Chou-Hong; McAllister, Timothy L.; Chiu, John S.; Colon, Cesar Process for the synthesis of azetidinones and intermediates for use as hypocholesterolemics PCT Int. Appl. (2000), WO 2000034240 A1 20000615.
[2] Thiruvengadam, Tiruvettipuram K.; Fu, Xiaoyong; Tann, Chou-hong; McAllister, Timothy L.; Chiu, John S.; Colon, Cesar Process for the synthesis of azetidinones U.S. (2001), US 6207822 B1 20010327.
[3] Thiruvengadam, Tiruvettipuram K.; Chiu, John S.; Fu, Xiaoyong; McAllister, Timothy L. Process for the synthesis of azetidinones U.S. Pat. Appl. Publ. (2006), US 20060135755 A1 20060622.
[4] Barden, Timothy C.; Lee, Peter; Martinez, Eduardo J.; Schairer, Wayne C.; Talley, John J. Processes for production of phenolic 4-biphenylylazetidin-2-ones PCT Int. Appl. (2006), WO 2006122216 A2 20061116.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Hypercholesterolemia

USEFUL LINKS

  PubChem