REVIEW Coenzyme B12 is one of the active forms of vitamin B12. As a nutritional supplement, it is available in tableted form, but not in injectable form. It has been used therapeutically to treat vitamin B12 deficiency. Vitamin B12 derivatives are also used to treat cyanide poisoning, and hereditary deficiency of transcobalamin II. Vitamin B12 consists of a class of chemically related compounds (vitamers), all of which have vitamin activity. It contains the biochemically rare element cobalt.
REFERENCES
[1]
Gruber, Karl; Puffer, Barbara; Kraeutler, Bernhard. Vitamin B12-derivatives - enzyme cofactors and ligands of proteins and nucleic acids. Chemical Society Reviews. (2011) 40(8): 4346-4363.
[2]
Marsh, E. Neil G.; Melendez, Gabriel D. Roman Adenosylcobalamin enzymes: Theory and experiment begin to converge. Biochimica et Biophysica Acta, Proteins and Proteomics. (2012) 1824(11): 1154-1164.
[3]
Brown, Kenneth L. The enzymatic activation of coenzyme B12. Dalton Transactions. (2006) (9): 1123-1133.
[4]
Roth J R; Lawrence J G; Bobik T A Cobalamin (coenzyme B12): synthesis and biological significance Annual review of microbiology (1996), 50, 137-81.
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