5289-74-7 20-Hydroxyecdysone AKSci V0682
 
 
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  V0682    AKSci Bulk Reagent
20-Hydroxyecdysone, 98% (HPLC)
 
Beta-Ecdysone
Ecdysterone
Crustecdysone
more..
IDENTITY
CAS Number:5289-74-7
MDL Number:MFCD00036740
MF:C27H44O7
MW:480.63
BRN:1917578
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:242-244°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 93mg/mL; H2O: <1mg/mL; EtOH: 93mg/mL; MeOH: 20mg/mL; Alcohol: soluble
Application(s):Ecdysteroid
Form:Free Base

REVIEW
 Beta-Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. It plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. BetaEcdysone is an Ecdysone receptor (EcR) agonist. It acts through a heterodimeric receptor comprising the ecdysone receptor (EcR) and the ultraspiracle proteins.

REFERENCES
[1]Ashburner, Michael; Richards, Geoff. The role of ecdysone in the control of gene activity in the polytene chromosomes of Drosophila. Symposium of the Royal Entomological Society of London. (1976) 8(Insect Dev.): 203-25.
[2] Swevers Luc; Iatrou Kostas. The ecdysone regulatory cascade and ovarian development in lepidopteran insects: insights from the silkmoth paradigm Insect. Biochemistry and Molecular Biology. (2003) 33(12): 1285-97.
[3] Fallon, Ann M.; Gerenday, Anna. Ecdysone and the cell cycle: Investigations in a mosquito cell line. Journal of Insect Physiology. (2010) 56(10): 1396-1401.
[4] Mori, Hiromu; Shibata, Kenyu Synthesis of ecdysterone Chemical & Pharmaceutical Bulletin (1969), 17(9), 1970-3

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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