V0740 Balsalazide - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # V0740
Balsalazide
, 98%
 



IDENTITY
CAS Registry #:[80573-04-2]
MDL Number:MFCD00868204
MF:C17H15N3O6
MW:357.3175
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:Orange powder
Shipping:Normal Temperature

REVIEW

 The mechanism of action of 5-aminosalicylic acid is unknown, but appears exert its anti-inflammatory effects locally (in the GI tract) rather than systemically. Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways (catalyzes the formation of prostaglandin precursors from arachidonic acid), and through the lipoxygenase pathways (catalyzes the formation of leukotrienes and hydroxyeicosatetraenoic acids from arachidonic acid and its metabolites), is increased in patients with chronic inflammatory bowel disease. Therefore, it is possible that 5-aminosalicylic acid diminishes inflammation by blocking production of arachidonic acid metabolites in the colon through both the inhibition of cyclooxygenase and lipoxygenase.

REFERENCES
[1]Wiggins JB, Rajapakse R: Balsalazide: a novel 5-aminosalicylate prodrug for the treatment of active ulcerative colitis. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1279-84.
[2] Ragunath K, Williams JG: Review article: balsalazide therapy in ulcerative colitis. Aliment Pharmacol Ther. 2001 Oct;15(10):1549-54.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


Pricing (not showing? please refresh your web browser)

CATEGORIES

 APIs and Bioactives > GI Diseases

USEFUL LINKS

  PubChem