65995-63-3 Punicalagin, tech. AKSci V1526
 
 
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  V1526    AKSci Bulk Reagent
Punicalagin, tech., ~40% (HPLC)
 
2,3-(S)-Hexahydroxydiphenoyl-4,6-(S,S)-gallagyl-D-glucose
IDENTITY
CAS Number:65995-63-3
MDL Number:MFCD09838017
MF:C48H28O30
MW:1084.72
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:~40% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>360°C
Long-Term Storage:Store long-term at 2-8°C
Note:Sold as technical grade. Not an analytical standard. No purity specification available.
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Carbonic Anhydrase Inhibitor
Form:Free Base

REVIEW
 Punicalagin is an ellagitannin, a phenolic compounds, with a alpha and beta form, found in pomegranates. It is the most abundant polyphenol in pomegranetes, and accounts for >50% of the antioxidant activity. Punicalagin is widely used for the treatment of inflammatory bowel disease (IBD), diarrhea, and ulcers. Since it could inhibit lipopolysaccharide -induced inflammation, it may be a potential choice for the treatment of inflammation diseases.

REFERENCES
[1]Tanaka, Takashi; Nonaka, Genichiro; Nishioka, Itsuo. Tannins and related compounds. XLI. Isolation and characterization of novel ellagitannins, punicacorteins A, B, C and D, and punigluconin from the bark of Punica granatum L. Chemical & Pharmaceutical Bulletin. (1986) 34(2): 656-63.
[2] Lin C C; Hsu Y F; Lin T C; Hsu F L; Hsu H Y. Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats. The Journal of Pharmacy and Pharmacology. (1998) 50(7): 789-94.
[3] Wang SG, Huang MH, Li JH, Lai FI, Lee HM, Hsu YN. Punicalagin induces apoptotic and autophagic cell death in human U87MG glioma cells. Acta Pharmacol Sin. (2013) Nov;34(11): 1411-9.
[4] Lopez Mas, Jose A.; Streitenberger, Sergio, A.; Penalver Mellado, Marcos; Martinez Ortiz, Pedro Process and apparatus for preparing pomegranate extracts Eur. Pat. Appl. (2008), EP 1967078 A1 20080910.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 25, 2024


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⚠️
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