V1656 Fasudil hydrochloride - AK Scientific
 
 
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  Catalog ID # V1656
Fasudil hydrochloride
, 98% (HPLC)
 
5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride
1-(5-Isoquinolinesulfonyl)homopiperazine Hydrochloride




IDENTITY
CAS Registry #:[105628-07-7]
MDL Number:MFCD00943198
MF:C14H18ClN3O2S
MW:327.83
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:LCMS, HPLC
Physical Form:White powder
Melting Point:208-215°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Application(s):Rho-kinase inhibitor and vasodilator

REVIEW

 RhoA/Rho kinase(ROCK) inhibitor that plays an important role in mediating vasoconstriction and vascular remodeling in the pathogenesis of PH. ROCK induces vasoconstriction by phosphorylating the myosin-binding subunit of myosin light chain (MLC) phosphatase, thus decreasing MLC phosphatase activity and enhancing vascular smooth muscle contraction.

REFERENCES
[1]Nagumo, H., Sasaki, Y., Ono, Y., Okamato, H., Seto, M., and Takuwa, Y. (2000). Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. American Journal of Physiology. 278: C57-C65.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Protein Kinase Inhibitors

USEFUL LINKS

  PubChem