269055-15-4 Etravirine AKSci X2931
 
 
Loading Please Wait...
  X2931    
Etravirine, 98% (HPLC)
 
TMC125
IDENTITY
CAS Number:269055-15-4
MDL Number:MFCD09837879
MF:C20H15BrN6O
MW:435.28
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:262-265°C
Flash Point:Not applicable°C
Density:1.439 g/cm3
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:water:0.00002 g/l at 25 °C (77 °F);
Application(s):Non-nucleoside reverse transcriptase inhibitor (NNRTI)

REVIEW
 Etravirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine.

REFERENCES
[1]Minuto, Joshua J.; Haubrich, Richard. Etravirine: a second-generation NNRTI for treatment-experienced adults with resistant HIV-1 infection. Future HIV Therapy. (2008) 2(6): 525-537.
[2] Seminari, E.; Castagna, A.; Lazzarin, A. Etravirine for the treatment of HIV infection. Expert Review of Anti-Infective Therapy. (2008) 6(4): 427-433.
[3] Scholler-Gyure, Monika; Kakuda, Thomas N.; Raoof, Araz; De Smedt, Goedele; Hoetelmans, Richard M. W. Clinical pharmacokinetics and pharmacodynamics of etravirine. Clinical Pharmacokinetics. (2009) 48(9): 561-574.
[4] De Corte, Bart; De Jonge, Marc Rene; Heeres, Jan; Ho, Chih Yung; Janssen, Paul Adriaan Jan; Kavash, Robert W.; Koymans, Lucien Maria Henricus; Kukla, Michael Joseph; Ludovici, Donald William; Van Aken, Koen Jeanne AlfonsPreparation of arylaminopyrimidines as inhibitors of HIV replication. PCT Int. Appl. (2000), WO 2000027825 A1 20000518.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H410

Precautionary Statements
P273; P391; P501

Current as of April 24, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Antivirals;NNRTIs


PubChem