85622-93-1 Temozolomide AKSci H027
 
 
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  H027    
Temozolomide, 98% (HPLC)
 
3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide
Methazolastone
Temodar
more..
IDENTITY
CAS Number:85622-93-1
MDL Number:MFCD00866492
MF:C6H6N6O2
MW:194.15
BRN:5547136
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:199-212°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):DNA damage inducer.
Form:Free Base

REVIEW
 Temozolomide is a DNA methylating agent and drug resistance-modifying agent; anti-tumor and anti-angiogenic. Temozolomide induces G2/M arrest and apoptosis through adduction of a methyl group to O6 position of guanine in genomic DNA and functional inactivation of DNA repair protein O(6)-alkylguanine DNA alkyltransferase (AGT) in base excision repair (BER) pathway.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H315; H319; H335; H340; H350; H360

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P308+P313; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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