51333-22-3 Budesonide AKSci H040
 
 
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  H040    AKSci Reference Standard
Budesonide, 98% (HPLC)
 
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
Rhinocort
Pulmicort
more..
IDENTITY
CAS Number:51333-22-3
MDL Number:MFCD00083259
MF:C25H34O6
MW:430.53
EINECS:257-139-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:235-245°C
Optical Rotation:+100° - +110° (c=0.28, CH2Cl2)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 86mg/mL; H2O: <1mg/mL; EtOH: 19mg/mL
Application(s):Inhibit Adrenocorticotropic hormone (ACTH) secretion
Form:Free Base

REVIEW
 The exact mechanism of action of budesonide in the treatment of Crohn's disease is not fully understood. However, being a glucocorticosteroid, budesonide has a high local anti-inflammatory effect.

REFERENCES
[1]Cope S, Kraemer M, Zhang J, Capkun-Niggli G, Jansen JP (2012). Efficacy of indacaterol 75 µg versus fixed-dose combinations of formoterol-budesonide or salmeterol-fluticasone for COPD: a network meta-analysis. Int J Chron Obstruct Pulmon Dis. 7:415-20. PMID 22848154.
[2] Deng X, Zhang Z, Gu W, Li Y, Liu M (2012). Budesonide inhibits interleukin-32 expression in a rat model of chronic obstructive pulmonary disease. Exp Lung Res. 38(6):295-301. PMID 22646473.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 24, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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