73573-88-3 Mevastatin AKSci I518
 
 
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  I518    AKSci Reference Standard
Mevastatin, 98% (HPLC)
 



IDENTITY
CAS Number:73573-88-3
MDL Number:MFCD05662341
MF:C23H34O5
MW:390.51
BRN:1269441
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:151-153°C
Optical Rotation:+283° (c=0.48, in acetone)
Density:1.136
Refractive Index:1.535
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 20 mg/mL, Ethanol 25 mg/mL
Application(s):Inhibitor of HMG-CoA reductase. Induces apoptosis

REVIEW
 Mevastatin (Compactin) inhibits HMGCR (HMG-CoA reductase) (Ki for acid form is 1 nM) which in turn inhibits isoprenoid biosynthesis and therefore blocks protein isoprenylation and reduces plasma cholesterol levels in humans. Mevastatin causes cells to arrest early in the G1 phase. Mevastatin is a close structural analog of lovastatin and both agents have the same biochemical and pharmacological activities. Mevastatin is inactive in cell-free assays. In cells however, it is hydrolyzed to the active free acid form by intracellular esterases.

REFERENCES
[1]Quesney-Huneeus, V., et al. 1979. Proc. Natl. Acad. Sci. U.S.A. 76: 5056-5060. PMID: 291922
[2] Quesney-Huneeus, V., et al. 1983. J. Biol. Chem. 258: 378-385. PMID: 6848509
[3] Evangelopoulos, M.E., et al. 2009. J. Neurosci. Res. 87: 2138-2144. PMID: 19224573
[4] Sugazaki, M., et al. 2010. Connect. Tissue Res. 51: 105-112. PMID: 20109072

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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